NCIG is building a trusted set of reference genome resources by generating whole genome sequence data using Illumina, PacBio HiFi, and Oxford Nanopore technologies. These datasets support high-quality research guided by Indigenous priorities, ensuring that future discoveries in genomic medicine are more accurate, inclusive, and culturally appropriate.

A key part of this work involves tackling some of the most challenging areas of the genome. We are developing ways to better understand structurally complex genomic regions and ribosomal DNA variation, both of which are critical for producing complete and reliable reference genomes. At the heart of NCIG’s genomic research agenda is the determination of whether newly identified genetic variants are linked to disease. We are achieving this by creating accurate, community-specific reference genomes and a population variation library, which together form a foundation for Indigenous-led genomic medicine.