Daniel is a group leader within the Analytic and Translational Genetics Unit ATGU) at Massachusetts General Hospital. He is also Assistant Professor at Harvard Medical School and a research Affiliate at the Broad Institute of Harvard and MIT.
Daniel completed his PhD at the Institute for Neuromuscular Research in Sydney, Australia, working on a loss-of-function variant in the human ACTN3 gene associated with variation in muscle strength and athletic performance. He then spent three years as a postdoctoral fellow at the Wellcome Trust Sanger Institute in Hinxton, UK, where he coordinated the annotation of genetic variants in protein-coding genes for the 1000 Genomes Project pilot study, which was published in Nature in 2010. More recently he led a large collaborative study analyzing human loss-of-function variants that was published in Science in February 2012.
Daniel's current research focuses on the extraction of functional information from massive-scale human DNA sequence data; his research program is described in more detail here, and his publications are listed here.